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08-9-1015-96/2003
Priority:1
Status: Approved for completion
in 2003

Radiation and Radiobiological Investigations
at the JINR Basic Facilities and in the Environment

Leader:    E.A. Krasavin
V.E. Aleinikov

Scientific Programme:
Radiation risk assessment is a crucial problem in occupational and public protection. It is well known that there is a lack of data needed to estimate risk of radiation stochastic effects (mutations and cancer diseases). Therefore, there is a need for obtaining new fundamental data on the induction of radiation stochastic effects for radiation with different linear energy transfer (LET). Accelerators and reactors of the Joint Institute are an excellent tool for modern radiation and radiobiological researches and give a unique possibility to obtain such data. The ultimate goal is to obtain fundamental physical and biological data based on experimental research at basic facilities of JINR and on theoretical modeling of ionizing radiation interaction with matter. Accelerators and radiochemistry facilities of JINR are able to produce different radionuclides for development of new radiopharmaceutical preparations as well. Research and development will include:
- LET and neutron spectrometry, radiation and biosensor monitoring;
- theoretical modeling of ionizing radiation interaction with matter including interactions with biological structures and shielding calculations;
- experimental data obtained for verification of theoretical modeling of ionizing radiation interaction with matter;
- investigations of peculiarities and mechanisms of point and structural mutation induction in pro- and eukaryotic cells by radiation with different LET;
- the problem of low doses of radiation with different LET and cell recovery;
- genetic and radiation monitoring of environment nuclear installations with biosensors and radiation monitors;
- investigation of "methylene blue - 211At" complex therapy efficiency in melanoma cells.

As the results:
- methods for radiation and genetic monitoring at nuclear installations of JINR and in environment will be developed;
- fundamental data for radiation risk assessments will be obtained;
- methods for targeted radiotherapy and diagnostics of melonoma will be developed.

Expected main results in 2003:


List of Activities
  Activity or project Spokespersons
Status
1. Radiation research V.E. Aleinikov
Preparation
Data taking
2. Radiobiological research E.A. Krasavin
Data taking
Realization
3. Project MITRA E.A. Krasavin
N.L. Shmakova
V.N. Korsounski
Data taking
4. Training activity V.E. Aleinikov
E.A. Krasavin
S.P. Ivanova
 


Collaboration   
Country or international
organization
City Institute or Laboratory
Armenia Yerevan YerPhI
Belarus Minsk IRB NASB
CERN
Czech Republic Brno IBP ASCR
Rez NPI ASCR
Germany Cologne DLR
Hungary Debrecen ATOMKI
JINR Dubna DLNP
FLNR
LIT
UC
VBLHE
Mongolia Ulaanbaatar NUM
Poland Otwock-Swierk IAE
Cracow NINP
Russia Moscow RCRC RAS
SRC-IBMP
Gatchina PNPI RAS
Puschino ITEB RAS
Slovak Republic Bratislava IPCM
Ukraine Kiev ICBGE NASU
Sevastopol IBSS NASU
USA Houston, TX NASA

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