THEME08-9-1015-96/2003

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08-9-1015-96/2003

Priority:

Status:

Approved for completion
in 2003

Radiation and Radiobiological Investigations
at the JINR Basic Facilities and in the Environment

Leader:

E.A. Krasavin
V.E. Aleinikov

Scientific Programme:
Radiation risk assessment is a crucial problem in occupational and public protection. It is well known that there is a lack of data needed to estimate risk of radiation stochastic effects (mutations and cancer diseases). Therefore, there is a need for obtaining new fundamental data on the induction of radiation stochastic effects for radiation with different linear energy transfer (LET). Accelerators and reactors of the Joint Institute are an excellent tool for modern radiation and radiobiological researches and give a unique possibility to obtain such data. The ultimate goal is to obtain fundamental physical and biological data based on experimental research at basic facilities of JINR and on theoretical modeling of ionizing radiation interaction with matter. Accelerators and radiochemistry facilities of JINR are able to produce different radionuclides for development of new radiopharmaceutical preparations as well. Research and development will include:
- LET and neutron spectrometry, radiation and biosensor monitoring;
- theoretical modeling of ionizing radiation interaction with matter including interactions with biological structures and shielding calculations;
- experimental data obtained for verification of theoretical modeling of ionizing radiation interaction with matter;
- investigations of peculiarities and mechanisms of point and structural mutation induction in pro- and eukaryotic cells by radiation with different LET;
- the problem of low doses of radiation with different LET and cell recovery;
- genetic and radiation monitoring of environment nuclear installations with biosensors and radiation monitors;
- investigation of "methylene blue - ²¹¹At" complex therapy efficiency in melanoma cells.

As the results:
- methods for radiation and genetic monitoring at nuclear installations of JINR and in environment will be developed;
- fundamental data for radiation risk assessments will be obtained;
- methods for targeted radiotherapy and diagnostics of melonoma will be developed.

Expected main results in 2003:

Main characteristics of the radiation fields at the JINR basic facilities and in the environment.
Calculations of nuclear facilities radiation shields.
Data about the regularities of induction of stable chromosomal aberrations in human lymphocytes after irradiation by high-energy carbon ions.
Data about the regularities of chromosomal aberrations in mammalian cells after low doses irradiation by carbon ions with 500 MeV/n energy.
Data about the regularities and mechanisms of mutagenic action of radiation with different LET on microorganisms. Continuation of the investigation of the genetic Check-point regulation in yeast cells.
The project "MITRA" - data about the distributions of ¹³¹I-MTB and ²¹¹At-MTB complexes in organisms of experimental animals with graft melanoma. Continuation of the investigation of dynamics of ¹³¹I- and ²¹¹At-MTB accumulation in different tissues of experimental animals.
Measurements of the dosimetric characteristics of the ²⁴Mg beam for the radiobiological experiments.

List of Activities

Activity or project

Spokespersons

Status

Radiation research

V.E. Aleinikov

Preparation
Data taking

Radiobiological research

E.A. Krasavin

Data taking
Realization

Project MITRA

E.A. Krasavin
N.L. Shmakova
V.N. Korsounski

Data taking

Training activity

V.E. Aleinikov
E.A. Krasavin
S.P. Ivanova

Collaboration
Country or international organization	City	Institute or Laboratory
Armenia	Yerevan	YerPhI
Belarus	Minsk	IRB NASB
CERN
Czech Republic	Brno	IBP ASCR
	Rez	NPI ASCR
Germany	Cologne	DLR
Hungary	Debrecen	ATOMKI
JINR	Dubna	DLNP
		FLNR
		LIT
		UC
		VBLHE
Mongolia	Ulaanbaatar	NUM
Poland	Otwock-Swierk	IAE
	Cracow	NINP
Russia	Moscow	RCRC RAS
		SRC-IBMP
	Gatchina	PNPI RAS
	Puschino	ITEB RAS
Slovak Republic	Bratislava	IPCM
Ukraine	Kiev	ICBGE NASU
	Sevastopol	IBSS NASU
USA	Houston, TX	NASA

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Radiation and Radiobiological Investigations at the JINR Basic Facilities and in the Environment

Radiation and Radiobiological Investigations
at the JINR Basic Facilities and in the Environment