\TNs{04--9--1077--2012/2014}{1}{\tsprg}
{Research on the Biological Effect of Heavy Charged Particles \\with Different Energies}
{E.A.~Krasavin\\G.N.~Timoshenko}
\TC{Armenia, Belarus, Bulgaria, Czech Republic, Egypt, Italy, Japan,
Moldova, Mongolia, Romania, Russia, Slovak Republic.}
%\bf Scientific Programme:%
\TA Theoretical and experimental research on the biological effect of heavy charged particles
with different energies at JINR's basic facilities.
The research and development will include:
\begin{itemize}
%1
\item Research on the effect of accelerated heavy ions of different energies on genetic structures.
%2
\item Research on the interaction between the main cataractogenic factors (ionizing radiation,
ultraviolet radiation, and age) during lens opacity formation.
%3
\item Research on the effect of different doses of accelerated charged particles on the retina
and central nervous system of experimental animals.
%4
\item Mathematical modeling of induced mutagenesis in bacterial and eukaryotic cells.
%5
\item Molecular dynamics modeling of spatial structures of complex protein aggregates
participating in DNA repair in bacterial and higher eukaryotic cells.
%6
\item Working out radiation protection measures for new nuclear physics facilities,
evaluation of their radiation environment, and development of radiation safety systems for them.
\end{itemize}
As the results:
\begin{itemize}
%1
\item Acquisition of new data on the regularities and mechanisms of the initiation of molecular
disorders in the DNA structure; DNA damage repair; and radiation-induced apoptosis
in human cells under radiations with different linear energy transfer (LET).
%2
\item Decoding of the mechanisms underlying cell hypersensitivity and hyperresistance to low
doses of ionizing radiation.
%3
\item Acquisition of comparative data on the regularities of the induction of gene and
structural mutations in mammalian and yeast cells by radiations with different LET.
%4
\item Drawing up recommendations on the threshold doses of heavy charged particles able
to damage the eye lens and retina. Development of the preventive measures against
cataract in persons occupationally exposed to irradiation with heavy charged particles.
%5
\item Research on the character of the heavy charged particle-induced damage of central
nervous system (CNS) cells and regularities of their death. Identification of the
heavy charged particle-induced functional disorders in the CNS.
%6
\item Molecular dynamics modeling of radiation-induced conformational changes in biological
structures.
%7
\item Mathematical modeling of the mutagenic effect of ionizing radiations with different
LET on bacterial and mammalian cells.
%8
\item Calculation of the radiation shielding of new nuclear physics facilities; evaluation
of the radiation environment and development of radiation safety systems.
%9
\item Research on the regularities in hematopoietic system damage formation in small
laboratory animals with different irradiation schemes.
%10
\item Evaluation of the radiation load on interplanetary mission crew members' organisms
depending on the solar cycle phase and shielding thickness.
%11
\item Estimation of the galactic radiation dose received by cosmonauts in different flight
scenarios for working out the criteria and grounds of the radiation safety standards
for interplanetary flights.
%12
\item Acquisition of new data on the performances of nanotechnology-based thermoluminescent
detectors.
\end{itemize}
\vspace*{4mm}
{\bf Expected main results in 2013:}
\begin{itemize}
%1
\item Continuation of research on the regularities of DNA damage induction and repair in
human and mammalian cells in the presence of modifiers of DNA replication and repair synthesis.
%2
\item Continuation of research on the mechanisms of radiation-induced apoptosis and
different ways of DNA damage repair under ionizing radiations of different qualities.
%3
\item Research on the regularities of the formation and repair of DNA double-strand breaks
and clustered damage using the method of DNA foci.
%4
\item Acquisition of data on the regularities of gene and structural mutation induction in
yeast cells by radiations of different linear energy transfer (LET).
%5
\item Acquisition of data on the regularities of the induction of structural damage in the
HPRT gene in mutant subclones of mammalian cells by radiations of different LET.
%6
\item Continuation of research on the mechanisms of the action of low doses of radiation of
different LET using modifiers of intracellular cytoprotector systems.
%7
\item Acquisition of data on the regularities in the functional disorders in the rodent retina
induced by radiations of different qualities and mutagens.
%8
\item Evaluation of the biological effect of Bragg peak protons for the total irradiation of mice.
%9
\item Teoretical evaluation of the radiation load on interplanetary flight crew depending
on the solar cycle phase and shielding thickness.
%10
\item Continuation of the development of methods of mathematical moderling of the heavy charged
particle effect on the central nervous system and visual apparatus of mammals.
%11
\item Development of approaches to the formulation of a new concept of the risk associated with
the effect of heavy charged particles of the space origin on living systems.
%12
\item Continuation of the development of models of the genetic control of the molecular mechanisms
in bacterial and mammalian cells under ionizing radiations of different LET.
%13
\item Carrying out dosimetry physics experiments at the Nuclotron (VBLHEP) and U-400M cyclotron (FLNR).
%14
\item Molecular dynamics modeling of the structural and functional properties of DNA photolyase and P53 protein.
%15
\item Calculation of the NICA collider shielding using the GEANT4 code.
\end{itemize}
\begin{stage-tr}
%1
\item \PS{Radiobiological research \\at charged particle beams}
{E.A.~Krasavin}{\psdt\\\psinp\\\psdt}
\PL{LRB}{}{A.N.~Abrosimova, S.V.~Aksenova, E.V.~Baranova, K.V.~Belokopytova, O.V.~Belov,
A.V.~Boreyko, A.N.~Bugay, N.N.~Budennaya, V.N.~Chausov, N.A.~Emelyanova,
T.A.~Fadeeva, R.D.~Govorun, E.V.~Ilyina, A.A.~Ivanov, A.A.~Khachenkova,
A.N.~Kokoreva, N.A.~Koltovaya, O.V.~Komova, I.V.~Koshlan, M.S.~Lyashko,
E.A.~Nasonova, A.Yu.~Parkhomenko, V.M.~Petrov, I.I.~Ravnachka, N.L.~Shmakova,
N.V.~Shvaneva, S.I.~Stukova, M.A.~Tuchina, S.V.~Vorozhtsova, A.Kh.~Yagova,
E.M.~Zaytseva, N.I.~Zhuchkina + 2 engineers, + 6 workers}
%2
\item \PS{Radiation research}{G.N.~Timoshenko}{\pspp\\\psdt\\\pspt}
\PL{LRB}{}{V.E.~Aleinikov, L.G.~Beskrovnaya, A.N.~Golovchenko, A.R.~Krylov, V.A.~Krylov,
E.N.~Lesovaya + 10 engineers, + 2 workers}
%3
\item \PS{Photoradiobiological research}{M.A.~Ostrovsky}{\null}
\PL{LRB}{}{T.B.~Feldman, D.M.~Kryuchkova, P.V.~Kutsalo, K.O.~Muranov, N.B.~Polyansky,
Yu.S.~Severyukhin, V.A.~Tronov, Yu.V.~Vinogradova + 1 engineers, + 1 workers}
%4
\item \PS{Computer molecular modeling}{Kh.T.~Kholmurodov}{\null}
\PL{LRB}{}{G.F.~Aru, E.B.~Dushanov, V.L.~Korogodina + 1 workers}
%5
\item \PS{Training activity}{V.E.~Aleinikov\\E.A.~Krasavin\\S.Z.~Pakuliak }{\null}
\PL{LRB}{}{V.E.~Aleinikov,M.V.~Altaisky, O.A.~Bakerin, E.V.~Baranova, O.V.~Belov,
A.V.~Boreyko, N.N.~Budennaya, T.B.~Feldman, R.D.~Govorun, A.A.~Ivanov,
Kh.T.~Kholmurodov, N.A.~Koltovaya, O.V.~Komova, M.M.~Komochkov, I.V.~Koshlan,
Yu.V.~Mokrov, M.A.~Ostrovsky, A.Yu.~Parkhomenko, V.M.~Petrov, G.N.~Timoshenko}
\PL{UC}{}{S.Z.~Pakuliak}
\end{stage-tr}
\begin{intcoop}
\mtab{Armenia}{Yerevan}{YSU}
\mtab{Belarus}{Gomel}{IRB NASB}
\mtab{Bulgaria}{Sofia}{IE BAS}
%\mtab{}{}{INRNE BAS}
\mtab{}{}{NCRRP}
\mtab{Czech Republic}{Brno}{IBP ASCR}
\mtab{}{\v Re\v z}{NPI ASCR}
\mtab{}{}{NRI}
\mtab{Egypt}{Giza}{CU}
\mtab{}{Cairo}{ASRT}
\mtab{}{}{EAEA}
\mtab{Italy}{Udine}{UNIUD}
\mtab{Japan}{Yokohama}{RIKEN}
%\mtab{Moldova}{Chi\c sin\u au}{UnASM}
\mtab{Mongolia}{Ulaanbaatar}{NUM}
\mtab{Poland}{Warsaw}{INCT}
\mtab{}{Krakow}{NINP PAS}
\mtab{Romania}{Bucharest}{UMF}
\mtab{}{}{ISS}
\mtab{}{Ia\c si}{UAIC}
\mtab{}{}{IBR}
\mtab{Russia}{Moscow}{MSU}
\mtab{}{}{MSMU}
\mtab{}{}{IBMP RAS}
\mtab{}{}{ITEP}
\mtab{Slovak Republic}{Bratislava}{CU}
%\mtab{Vietnam}{Hanoi}{NCNST VAST}
%\mtab{India}{New Delhi}{IUAC}
\end{intcoop}
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
\TN{04--9--1112--2013/2015}{1}{\tsnew}
{Research on Cosmic Matter on the Earth and in Nearby Space;\\
Research on the Biological and Geochemical Specifics of the Early Earth}
{E.A.~Krasavin\\A.Yu.~Rozanov \\V.N.~Shvetsov}
\TC{Italy, Norway, Poland, Romania, Russia, United Kingdom, USA.}
%\bf Scientific Programme:%
\TA
Research and development will include:
- Biogeochemical studies of cosmic dust
%2
- Studies of biofossils and organic compounds in meteorites and ancient terrestrial rocks
%3
- Studies of cosmic matter with nuclear physics methods
%4
- As a result of studying and generalizing the research materials on modern and fossil cosmic
dust as well as ancient terrestrial objects and modern organisms of the extreme ecosystems,
data will be obtained on the forms of ancient terrestrial and extraterrestrial life.
As the results:
- Obtaining new data on the amount of cosmic matter falling on the whole Earth's surface.
%2
- Obtaining data on the dynamics of cosmic dust fallout on large territories.
%3
- Evaluation of the following parameters of particles of extraterrestrial origin
(focusing on carbonaceous chondrites): morphology, structure, size distribution, and elemental,
isotopic, and mineralogical composition. Assessment of changes in these characteristics in different plates
in different time intervals.
%4
- Creation of a cosmic dust collection, where dust microparticles will be characterized by quantity
(concentration) and the size distribution.
%5
- Cosmic dust research with spacecraft at the altitudes of 300 - 600 km: data generalization; creation of
a comparative collection that is necessary for the isolation of the space component of the samples from
the Earth's surface.
%6
- Obtaining new information on the role of microorganisms in the formation and evolution of life on the Earth
and processes of weathering, precipitation growth, etc.
%7
- Obtaining data on Archaean and Proterozoic microfossils (including possible eukaryotic organisms) from different
regions and microfossils in ancient residual soils and volcanogenic sedimentary rocks. The new data will be compared
with data on younger - Phanerozoic - rocks.
%8
- Generalization of the obtained data on the forms of ancient terrestrial and extraterrestrial life.
%%\vspace*{4mm}
{\bf Expected main results in 2013:}
\begin{itemize}
%1
\item Detection and study of biofossils and organic matter in meteorites and the most ancient terrestrial rocks.
%2
\item Development of methods of detecting microorganism remnants in Archean and Proterozoic rocks and evaluating the level of their organization.
\end{itemize}
\begin{stage-tr}
%1
\item \PS{Studies of biofossils in meteorites and ancient terrestrial rocks}{A.Yu. Rozanov\\E.A.~Krasavin}{\psdt\\ \psinp\\ \psmod}
\PL{LRB}{}{+~2 pers.}
%2
\item \PS{Biogeochemical and biological studies of cosmic dust}{L.M.~Gindilis}{\psdt\\ \psinp\\ \psmod}
\PL{LRB}{}{+~3 pers.}
%3
\item \PS{Cosmic matter research with nuclear physics methods}{V.N.~Shvetsov }{\psdt\\ \psinp\\ \psmod}
\PL{FLNP}{}{I.A.~Bobrikov, A.Yu.~Dmitriev, P.V.~Sedyshev, M.V.~Frontasyeva}
\end{stage-tr}
\begin{intcoop}
%\mtab{Azerbaijan}{Baku}{ANAS}
\mtab{Italy}{Rome}{Univ. "La Sapienza"}
\mtab{}{Viterbo}{UNTUS}
%\mtab{Mongolia}{Ulaanbaatar}{MAS}
\mtab{Norway}{Trondheim}{NTNU}
\mtab{Poland}{Poznan}{AMU}
\mtab{Romania}{Bucharest}{UB}
\mtab{Russia}{Moscow}{IGEM RAS}
\mtab{}{}{IKI RAS}
\mtab{}{}{MSU}
\mtab{}{}{PIN RAS}
\mtab{}{}{SAI MSU}
\mtab{}{Borok}{IPE RAS}
\mtab{}{Gatchina}{PNPI}
\mtab{}{Novosibirsk}{BIC SB RAS}
\mtab{United Kingdom}{Buckingham}{UB}
\mtab{USA}{Athens, AL}{ASU}
\end{intcoop}