Awards for JINR scientists

FLNP leading researcher Mikhail Kiselev won the Pharmaceutics 2022 Best Paper Award for his article "Liposome production methods: factors of development and control of universal nanocarriers for biomedicine and nanomedicine", co-authored with senior researcher at the University of Messina Domenico Lombardo.

The basic features of the development and manufacturing technology of liposomal nanocarriers, with a special emphasis on the structure, parameters and critical factors influencing the development of a suitable stable formulation are analyzed in the article. The late developments and new techniques for producing liposomes are also discussed.

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A team of authors with the participation of JINR was awarded the prestigious Galileo Galilei Award 2023 of the European Journal of Medical Physics (Physica Medica) for the paper "Prediction of DNA reunification kinetics and cell survival after proton irradiation of V79 cells using Geant4-DNA" within the framework of the international Geant4-DNA collaboration.

The goal of the research was to expand the radiobiological application of the Geant4-DNA code by including functions that allow predicting the kinetics of DNA repair and determining the corresponding proportion of surviving cells over time after irradiation for the V79 cell line - one of the most popular and widely studied cell lines in radiobiology. For the first time, within the framework of a unified prototype approach, scientists managed to link the implementation of cell survival processes after irradiation with the kinetics of DNA reunification along with an estimation of the initial damage. The investigations were carried out using a realistic prototype of the cell nucleus developed by the authors that allows estimating DNA damage based on simulating the structure of a track of charged particles with different linear energy transfer. The proposed calculation approaches allowed linking into a single prototype the DNA damage mechanisms taking into account the physical and chemical stage and DNA reparation processes along several key recovery pathways.